The Impact of Baseline User Characteristics on the Benefits of Real-Time Versus Intermittently Scanned Continuous Glucose Monitoring in Adults With Type 1 Diabetes: Moderator Analyses of the ALERTT1 Trial
Authors' conclusion
Except for HFS-worry score, no interactions between 14 baseline characteristics and the six-month intervention effect of rtCGM on TIR, HbA1c, or time <54 mg/dL were observed, supporting the conclusion of ALERTT1 that switching from isCGM without alerts to rtCGM with alert functionality is beneficial for a wide range of people with T1D.
Study context
- Population
- Adults with T1D in the ALERTT1 trial
- Comparison
- Real-time CGM (rtCGM) with alerts vs intermittently scanned continuous glucose monitoring (isCGM) without alerts
- Primary endpoint
- Dependency of the difference (delta) in mean TIR, HbA1c, time <54 mg/dL and HFS-worry score between rtCGM and isCGM on 14 baseline characteristics
- Follow-up
- Six months
Methodological detailspost hoc, moderator analyses
- Post hoc
- Moderator analyses
Primary result
As reported in the abstract
Moderation of rtCGM vs isCGM effect by 14 baseline characteristics
- Delta HFS-worry score depended on baseline HbA1c; less worries with rtCGM in people with baseline HbA1c <6.5% or ≥8%
- P = .0059
Original publication
The Impact of Baseline User Characteristics on the Benefits of Real-Time Versus Intermittently Scanned Continuous Glucose Monitoring in Adults With Type 1 Diabetes: Moderator Analyses of the ALERTT1 Trial. J Diabetes Sci Technol. Published 29 September 2022. doi:10.
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