Impact of 24-week concurrent training on bone parameters and plasma levels of osteoglycin and sclerostin in young, sedentary adults: secondary analyses from the ACTIBATE randomized controlled trial
Authors' conclusion
24 weeks of concurrent training did not alter bone parameters, and plasma levels of osteoglycin and sclerostin in young, sedentary adults. Moreover, osteoglycin and sclerostin are not related with bone parameters and cardiometabolic risk factors in this population. These findings suggest that longer concurrent training interventions may be needed to enhance bone parameters in young, sedentary adults.
Study context
- Population
- Young, sedentary men and women; University of Granada106 per-protocol
- Participants
- 145 participants
- Comparison
- 24-week moderate or vigorous-intensity concurrent training vs control
- Control (CON)n = 54reference
- MOD-EXn = 48
- VIG-EXn = 43
Primary result
As reported in the abstract
Changes in bone parameters (DXA), plasma osteoglycin and sclerostin · 24 weeks
- No differences in changes in bone parameters, osteoglycin and sclerostin levels
- Between MOD-EX and CON: all P time × group ≥ .300
- Between MOD-EX and CON: P time × group = .250
- Between MOD-EX and CON: P time × group = .489
- Per-protocol analyses
Further findings
Correlations of osteoglycin and sclerostin with body composition and cardiometabolic risk factors
All P ≥
- No correlation with body composition
- .639
- No correlation with cardiometabolic risk factors
- .119
Original publication
Impact of 24-week concurrent training on bone parameters and plasma levels of osteoglycin and sclerostin in young, sedentary adults: secondary analyses from the ACTIBATE randomized controlled trial. Eur J Endocrinol. Published 29 April 2025. doi:10.
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