Immune profile of adipose tissue from youth with obesity and asthma
Authors' conclusion
Enrichment of macrophage-mediated inflammation in VAT from youth with obesity-related asthma supports its role in systemic inflammation linked with asthma morbidity. Lack of correlation of VAT cells with metabolic dysregulation in youth with obesity-related asthma identifies a need to define distinguishing factors associated with VAT inflammation in obesity-related asthma.
Study context
- Population
- Youth with obesity, with or without asthma; visceral adipose tissue (VAT) samples
- Participants
- 14 vs 23
- Exposure
- Youth with obesity-related asthma vs obesity without asthma
- Obesity-related asthman = 14
- Obesity without asthman = 23reference
- Outcome
- VAT stromal vascular fraction cellular profile
Methodological detailsflow cytometry of visceral adipose tissue stromal vascular fraction
- Flow cytometry of visceral adipose tissue stromal vascular fraction
Main finding
As reported in the abstract
- VAT in obesity-related asthma enriched for leukocytes and macrophages, incl. M1 and dual M1M2 cells, vs no asthma
- No difference for CD4+ lymphocytes, endothelial cells, their progenitors and preadipocytes
Observational data: associations, not effects.
Further findings
Correlation of VAT cells with metabolic measures
- In obesity without asthma: M1 macrophage counts correlated positively with glucose; M1M2 cells, CD4+ lymphocytes and subsets correlated negatively with HDL; not in obesity-related asthma
Original publication
Immune profile of adipose tissue from youth with obesity and asthma. Pediatr Obes. Published 4 October 2023. doi:10.
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