The Association between Vitamin D Deficiency and Hepatosteatosis in Children and Adolescents with Obesity
Authors' conclusion
Serum 25(OH)D concentrations were lower in children and adolescents with obesity and hepatic steatosis as compared to those without hepatic steatosis, with an inverse association between the severity of hepatosteatosis and serum 25(OH)D concentrations. Vitamin D treatment in children and adolescents with obesity and hypovitaminosis D did not improve severity of hepatic steatosis on ultrasonography at 6 months.
Study context
- Population
- Children and adolescents with obesity (BMI >+2 SDs for age and gender) and vitamin D deficiency (serum 25(OH)D <12 ng/mL)
- Participants
- 133 children
- Exposure
- Children with obesity with hepatosteatosis vs without hepatosteatosis; before vs 6 months after vitamin D treatment
- Outcome
- Serum 25(OH)D
- Follow-up
- Baseline
Methodological detailsbefore-after vitamin D treatment
- Before-after vitamin D treatment
Main finding
As reported in the abstract
P < 0.005
Observational data: associations, not effects.
Further findings
Hepatosteatosis grade at baseline
- Grade 1
- 51 (38.4%)
- Grade 2
- 43 (32.3%)
- Grade 3
- 10 (7.5%)
Independent predictors of hepatosteatosis (multivariable logistic regression)
- Serum 25(OH)D independent predictor
- P < 0.005
- Age, sex, weight SD, BMI SD, HOMA-IR not predictors
- P > 0.05
BMI SD, HOMA-IR and liver enzymes, with vs without hepatosteatosis
- No significant difference
- P > 0.05
Serum 25(OH)D after vs before vitamin D treatment · 6 months post-treatment
- 34.7 ± 10.6 ng/mL vs 8.7 ± 2.4 ng/mL
- P < 0.0001
Proportion with different hepatosteatosis severity after vs before treatment · 6 months
- No significant difference
- P = 0.88
Original publication
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