Insulin glargine/lixisenatide (iGlarLixi) (insulin glargine 100 U / ml plus lixisenatide) is effective and well tolerated in people with uncontrolled type 2 diabetes regardless of age: A REALI pooled analysis of prospective real‐world data
Authors' conclusion
iGlarLixi is effective and well tolerated in both younger and older people with uncontrolled T2D.
Study context
- Population
- Adults with T2D inadequately controlled on oral antidiabetic drugs with or without basal insulin who initiated iGlarLixi for 24 weeks
- Participants
- 1,316 adults
- Comparison
- iGlarLixi in people aged ≥65 years vs <65 years
- ≥65 yearsn = 510
- <65 yearsn = 806reference
- Outcome
- Least-squares adjusted mean change in HbA1c from baseline
- Follow-up
- 24 weeks
Methodological detailspatient-level pooled data, routine clinical practice
- Patient-level pooled data
- Routine clinical practice
Pooled result
As reported in the abstract
≥65 years
−1.55
least-squares adjusted mean · 95% CI −1.65%–-1.44% · %
<65 years
−1.42
least-squares adjusted mean · 95% CI −1.50%–-1.33% · %
95% CI −0.26% to 0.00%; P = 0.058 between subgroups
Further pooled results
Mean, kg
| Outcome | ≥65 years | <65 years |
|---|---|---|
| Mean body weight change from baseline · week 24 | −1.6 | −2.0 |
Baseline characteristics
- Mean BMI, ≥65 vs <65 years (kg/m²)
- 31.6 vs. 32.6
- Median diabetes duration, ≥65 vs <65 years (years)
- 11.0 vs. 8.0
- Prior basal insulin, ≥65 vs <65 years
- 48.4% vs. 43.5%
- Mean HbA1c, ≥65 vs <65 years
- 8.93% [74.10 mmol/mol] vs. 9.22% [77.28 mmol/mol]
Safety
Gastrointestinal adverse events and hypoglycaemic episodes
- Low incidences of gastrointestinal AEs and hypoglycaemic episodes in both age subgroups
Original publication
iGlarLixi (insulin glargine 100 U / ml plus lixisenatide) is effective and well tolerated in people with uncontrolled type 2 diabetes regardless of age: A REALI pooled analysis of prospective real‐world data. Diabetes Obes Metab. Published 21 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →