Identification and Follow-up of At-Risk Children Mitigate Disease Severity and Improve Treatment Outcomes in Type 1 Diabetes
Authors' conclusion
DIPP participants had a milder clinical presentation at T1D diagnosis, with lower HbA1c levels and lower insulin requirements during the first year.
Study context
- Population
- Children with T1D diagnosis
- Participants
- 126 vs 440
- Exposure
- At-risk children followed in Diabetes Prediction and Prevention (DIPP) vs children diagnosed outside the screening program
- DIPPn = 126
- Non-DIPPn = 440reference
- Outcome
- DKA at T1D diagnosis
- Follow-up
- At diagnosis
Methodological detailsprospective follow-up, population-based genetic screening
- Prospective follow-up
- Population-based genetic screening
Main finding
As reported in the abstract
P < 0.05
Observational data: associations, not effects.
Further findings
HbA1c · at diagnosis
HbA1c % DIPP 6.4% · Non-DIPP 11.2%
HbA1c · 1 year
HbA1c % DIPP 7.2% · Non-DIPP 7.7%
Insulin requirement · at diagnosis
Insulin requirement · 1 year
Dehydration, electrolyte imbalances, need for intensive care, inpatient stay · at diagnosis
- Significantly less frequent dehydration, electrolyte imbalances and need for intensive care, and shorter inpatient stays, in DIPP vs non-DIPP (P < 0.05)
Original publication
Identification and Follow-up of At-Risk Children Mitigate Disease Severity and Improve Treatment Outcomes in Type 1 Diabetes. Diabetes Care. Published 11 June 2026. doi:10.
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