Altered Glucagon Response to Oral Glucose in Individuals at Different Stages of Type 1 Diabetes Development
Authors' conclusion
These findings highlight the need for prospective studies to further elucidate the role of α cells in disease progression and support testing pharmacotherapies aimed at improving both α- and β-cell functions during disease development.
Study context
- Population
- Participants aged 4 to 25 years from the Finnish Diabetes Prediction and Prevention (DIPP) study
- Participants
- 47 participants
- Exposure
- Glucagon response to oral glucose tolerance test (OGTT) across stages of T1D development
- Outcome
- Glucagon concentrations during a 6-point OGTT (conventional radioimmunoassay)
Main finding
As reported in the abstract
Glucagon during OGTT
- Fasting plasma glucagon levels increased with disease progression
- Longitudinal patterns of glucagon concentrations during the OGTT differed significantly between groups
- Paradoxical 15-minute glucagon increase observed only in individuals at early stage 3 of T1D
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Altered Glucagon Response to Oral Glucose in Individuals at Different Stages of Type 1 Diabetes Development. J Clin Endocrinol Metab. Published 31 October 2025. doi:10.
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