Hypoglycemia Caused by Exogenous Insulin Antibody Syndrome: A Large Single-Center Case Series From China
Authors' conclusion
Predisposing factors for autoimmune hypoglycemia caused by EIAS include a strong autoimmune background. Susceptible HLA genotypes for type 1 diabetes or insulin autoimmune syndrome might not explain susceptibility to this condition. Additionally, insulin autoantibodies and the insulin/C-peptide molar ratio are reliable screening options. The prognosis for this condition is favorable. Monitoring of insulin and insulin autoantibodies may contribute to treatment effectiveness.
Study context
- Population
- Patients with diabetes and autoimmune hypoglycemia caused by exogenous insulin antibody syndrome (EIAS), ChinaHuman leukocyte antigen (HLA) genotyping in 10
- Participants
- 23 patients
- Outcome
- Clinical characteristics of autoimmune hypoglycemia caused by EIAS
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Autoimmune comorbidities
- 21.7%
- Food or drug allergy
- 48%
- Insulin allergy
- 30%
- Lipodystrophy at insulin injection sites
- 22%
- Antinuclear antibodies
- 25%
- Alternation between hyperglycemia and hypoglycemia
- more than 90%
- High insulin autoantibody titer
- >90%
- Insulin/C-peptide molar ratio >7
- >85%
- Spontaneous remission rate
- exceeded 70%
Observational data: associations, not effects.
Further findings
HLA genotypes
- Frequencies of DRB1*0405-DQB1*0401 and DRB1*0901-DQB1*0303 similar to those previously reported in T1D
- Lower frequency of DRB1*0406 vs insulin autoimmune syndrome
Original publication
Hypoglycemia Caused by Exogenous Insulin Antibody Syndrome: A Large Single-Center Case Series From China. J Clin Endocrinol Metab. Published 11 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →