Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes
Authors' conclusion
Our findings support the concept that oxidative stress, and neoantigenic epitopes of insulin, may be involved in the immunopathogenesis of type 1 diabetes.
Study context
- Population
- Sera from 63 participants with new-onset T1D and 30 controls; fresh blood from 18 recently diagnosed, 5 established T1D and 11 controls
- Participants
- 63 vs 30
- Comparison
- T1D vs control participants
- T1Dn = 63
- Controln = 30reference
- Outcome
- Antibody and T cell responses to oxPTM-INS peptides
Methodological detailscase-control
- Case-control
Main finding
As reported in the abstract
- Antibody and T cell responses to insulin peptide candidates
- three out of six
- T1D: CD4+ response to oxPTM-INSP-6 vs Nt-INSP-6 (p=0.045)
- 66.7% vs 27.8%
- T1D patients with concordant CD4+, CD8+ and autoantibody response to oxPTM-INSP
- 44.4%
Original publication
Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes. Diabetologia. Published 7 October 2022. doi:10.
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