Hyperglycemia Suppresses Lactate Clearance During Exercise in Type 1 Diabetes
Authors' conclusion
Hyperglycemia modulates lactate metabolism during exercise by lowering CL, leading to higher circulating lactate concentrations in T1D individuals. This novel observation implies that exercise during hyperglycemia can lead to higher circulating lactate concentrations thus increasing the likelihood of reaching the lactate threshold sooner in T1D, and has high translational relevance both for providers and recreationally active people with T1D.
Study context
- Population
- Individuals with T1D and without diabetes, University of Virginia
- Participants
- 7 / 7 / 7
- Comparison
- Hyperglycemia vs euglycemia during exercise in T1D; T1D vs ND at euglycemia
- T1D hyperglycemian = 7
- T1D euglycemian = 7reference
- NDn = 7
- Outcome
- Lactate turnover before, during and after exercise at 65% VO2max
- Follow-up
- 60 minutes of exercise
Methodological detailsrandom order of euglycemia and hyperglycemia visits in T1D, [1-13C] lactate infusion
- Random order of euglycemia and hyperglycemia visits in T1D
- [1-13C] lactate infusion
Main finding
As reported in the abstract
Lactate kinetics during exercise
- A 2-compartment model with loss only from the peripheral compartment described lactate kinetics
- No differences in any of these parameters between T1D and ND during euglycemia
- T1D hyperglycemia vs T1D euglycemia: P = 0.03
- T1D hyperglycemia vs T1D euglycemia: P < 0.001
- T1D hyperglycemia vs T1D euglycemia: P = 0.13
Further findings
- Volume of distribution of the accessible compartment — Concordant with plasma volume · T1D euglycemia vs ND · similar between T1D and ND
- ∼40 mL/kg · P = 0.76
Original publication
Hyperglycemia Suppresses Lactate Clearance During Exercise in Type 1 Diabetes. J Clin Endocrinol Metab. Published 4 January 2024. doi:10.
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