Hyperglycemia: A determinant of cardiac autonomic dysfunction in youth with obesity across the spectrum of glycemic regulation
Authors' conclusion
Youth with impaired glucose regulation have evidence of cardiac autonomic dysfunction with decreased HRV, and sympathetic overdrive (increased LF/HF). This dysfunction is mainly related to glycemia and systemic inflammation.
Study context
- Population
- Adolescents (15 ± 2.1 years) with obesity across the glycemia spectrum and normal-weight controls
- Participants
- 94 adolescents
- Exposure
- Normal weight vs overweight-normal glucose tolerance vs prediabetes vs T2D
- Normal weightn = 21reference
- Overweight-normal glucose tolerancen = 23
- Prediabetesn = 26
- T2Dn = 24
- Outcome
- Determinants of heart rate variability (HRV) (LF/HF ratio) by peripheral arterial tonometry
Main finding
As reported in the abstract
LF/HF (HRV frequency-domain index)
- LF/HF correlation with %body fat
- r = 0.22, p = 0.04
- LF/HF correlation with fasting glucose
- r = 0.39, p < 0.001
- LF/HF correlation with 2-h glucose
- r = 0.31, p = 0.004
- LF/HF correlation with AUC glucose
- r = 0.32, p = 0.003
- LF/HF correlation with hs-CRP
- r = 0.33, p = 0.002
- LF/HF correlation with TNF-α
- r = 0.38, p = 0.006
- Linear regression, Ln LF/HF: fasting glucose
- β = 0.39, p = 0.003
- Linear regression, Ln LF/HF: hs-CRP
- β = 0.21, p = 0.09
- Regression model
- R2 = 0.23, p = 0.013
Observational data: associations, not effects.
Original publication
Hyperglycemia: A determinant of cardiac autonomic dysfunction in youth with obesity across the spectrum of glycemic regulation. Pediatr Obes. Published 13 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →