Hybrid Closed Loop in Adolescents and Young Adults Living with Type 1 Diabetes: A Real-World Study
Authors' conclusion
Youth with type 1 diabetes can improve metabolic control thanks to HCL without increasing complication risk.
Study context
- Population
- Youth aged 15–25 years with T1D, including people with very poor metabolic control
- Participants
- 101 participants
- Exposure
- Hybrid closed loop (HCL): before vs after initiation
- HCLn = 101
- Outcome
- Long-term metabolic outcomes (HbA1c) and safety of HCL
- Follow-up
- Mean 16 (±6; 3-31) months
Methodological detailsobservational, monocentric, real-world
- Observational
- Monocentric
- Real-world
Main finding
As reported in the abstract
HbA1c · mean 16 months follow-up
- HbA1c at baseline
- 9.6% ± 2.3% (82 ± 25 mmol/mol)
- HbA1c at follow-up
- 8.0% ± 1.4% (64 ± 15 mmol/mol)
- Decrease from baseline
- P < 0.001
Observational data: associations, not effects.
Further findings
CGM parameters
- GMI decreased
- 8.8% to 7.9%
- TIR increased
- 39% to 57%
- TBR decreased
- 3.0% to 1.6%
- CGM parameters trend
- P < 0.001
Discontinued HCL
- Patients discontinued HCL
- 10
Safety
Severe hypoglycaemia and DKA
- No more severe hypoglycemia or DKA under HCL vs the year before HCL initiation
Retinopathy
Cases
- New onset retinopathy
- 5
- Worsening retinopathy
- 4
Original publication
Hybrid Closed Loop in Adolescents and Young Adults Living with Type 1 Diabetes: A Real-World Study. Diabetes Technol Ther. Published 10 April 2025. doi:10.
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