Hormonal adaptations to weight loss: Responses to an oral glucose load 4 weeks after obesity surgery and low‐energy diet
Authors' conclusion
Rapid and extensive hormonal changes occur after OS, but not LED, despite similar weight loss. Of note, few differences were seen in the fasting state, whereas multiple endocrine pathways were affected during the oral glucose challenge. The findings suggest altered responses to oral glucose after OS in several hypothalamus-pituitary endocrine axes and peripheral endocrine glands.
Study context
- Population
- Adults with obesity but without diabetes (BMI 35–45 kg/m²)randomized 2:1
- Participants
- 24 adults
- Comparison
- Obesity surgery vs 4-week low-energy diet
Methodological detailssub-analyses, randomized 2:1
- Sub-analyses
- Randomized 2:1
Primary result
As reported in the abstract
4 weeks
- GLP-1 and peptide YY secretion during oral glucose tolerance test (OGTT) increased after obesity surgery (OS), but not low-energy diet (LED) (OGTT AUC, both hormones)
- p < 0.001
- ACTH during OGTT increased after OS
- p = 0.04
- Cortisol during OGTT increased after OS
- p < 0.001
- PRL during OGTT increased after OS
- p = 0.002
- PTH during OGTT decreased after OS
- p = 0.007
- Fasting triiodothyronine reduced after OS
- p = 0.01
- Fasting SHBG decreased after both interventions
- p < 0.01
Further findings
Weight loss · 4 weeks
Weight loss · 4 weeks
- Similar weight loss with the two interventions
Original publication
Hormonal adaptations to weight loss: Responses to an oral glucose load 4 weeks after obesity surgery and low‐energy diet. Diabetes Obes Metab. Published 16 June 2025. doi:10.
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