HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the The Environmental Determinants of Diabetes in the Young (TEDDY) Study
Authors' conclusion
Timing of solid food introduction, including rice, may be associated with IA in children with the HLA DR3/4 genotype not exposed to probiotics. The microbiome composition under these exposure combinations requires further study.
Study context
- Population
- Children with increased genetic risk of T1D, TEDDY studyof 8,676 followed
- Participants
- 7,770 children
- Exposure
- Early (<6 months) vs later solid food introduction, by HLA genotype and probiotic exposure
- Outcome
- Islet autoimmunity (IA)
Methodological detailsCox proportional hazards regression adjusted for potential confounders
- Cox proportional hazards regression adjusted for potential confounders
Main finding
As reported in the abstract
IA
- Any solid food introduced early (<6 months) associated with increased risk of islet autoimmunity (IA) if HLA DR3/4 genotype and no probiotic exposure in 1st year of life
Observational data: associations, not effects.
Further findings
IA, rice introduction in the U.S.
- Rice introduced at 4-5.9 months vs later in the U.S. associated with increased risk of IA
Original publication
HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study. Diabetes Care. Published 14 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →