Higher Risk of Incident Hyperthyroidism in Patients With Atrial Fibrillation
Authors' conclusion
Our results provide insight into clinical risk factors for the development of hyperthyroidism in AF patients, as identified by the novel SAD HEC2 score. AF appears to be a common precursor of hyperthyroidism.
Study context
- Population
- Patients aged ≥18 years with atrial fibrillation (AF) but without hyperthyroidism at diagnosis, tertiary medical institution
- Participants
- 8,552 patients
- Exposure
- Patients with vs without incident hyperthyroidism
- Outcome
- Newly diagnosed hyperthyroidism
- Follow-up
- During
Methodological detailssingle-centre, tertiary medical institution
- Single-centre
- Tertiary medical institution
Main finding
As reported in the abstract
- Younger age, female gender, history of congestive HF, hypertension, diabetes, non-ESRD status and lower CHADS2 score, but not CHA2DS2-VASc, were independent predictors of incident hyperthyroidism
- Novel SAD HEC2 risk score had excellent predictive power for incident hyperthyroidism
Observational data: associations, not effects.
Further findings
Baseline characteristics: incident hyperthyroidism vs no hyperthyroidism
P = 0.121
Baseline characteristics: incident hyperthyroidism vs no hyperthyroidism
P < 0.001
Baseline characteristics: incident hyperthyroidism vs no hyperthyroidism
P < 0.001
Baseline characteristics: incident hyperthyroidism vs no hyperthyroidism
P < 0.001
Baseline characteristics: incident hyperthyroidism vs no hyperthyroidism
P = 0.001
| Outcome | Incident hyperthyroidism | No incident hyperthyroidism | P value |
|---|---|---|---|
| Baseline characteristics: incident hyperthyroidism vs no hyperthyroidism | 1.74 | 2.05 | P = 0.031 |
Baseline characteristics: incident hyperthyroidism vs no hyperthyroidism
- Patients developing hyperthyroidism were younger, with a higher proportion of females
- No statistically significant difference in CHA2DS2-VASc and HAS-BLED score
Original publication
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