Higher peak height velocity in early maturing girls depends on insulin rather than fat mass or IGF-I
Authors' conclusion
Growth velocity was higher and more prolonged in early compared with late maturing girls and associated with higher insulin levels. Thus, the higher insulin levels may compensate for the shorter total growth period by intensifying the pubertal growth period.
Study context
- Population
- Girls evaluated biannually for a median of 10 (2–15) visits, 815 evaluations in total; COPENHAGEN puberty study815 evaluations
- Participants
- 81 participants
- Exposure
- Early vs late maturing girls
- Outcome
- PHV
Methodological detailspart of the COPENHAGEN puberty study
- Part of the COPENHAGEN puberty study
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Final height · similar final height
P = 0.36
Puberty duration (age at onset of breast development to age at PHV) · longer with early maturation
P < 0.001
- Fasting insulin levels · 1.5, 2.0, and 3.0 years after pubertal onset · significantly higher with early maturation
- all P = .039
BMI, skin fold thickness and IGF-I levels
- After correcting for age at pubertal onset, neither BMI, skin fold thickness (SFT) nor IGF-I levels differed between early vs late maturing girls
Original publication
Higher peak height velocity in early maturing girls depends on insulin rather than fat mass or IGF-I. Eur J Endocrinol. Published 18 September 2024. doi:10.
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