High stress hyperglycemia ratio predicts adverse clinical outcome in patients with coronary three-vessel disease: a large-scale cohort study
Main finding · CV eventsResult — go to the resultHazard ratio 1.99 95% CI 1.58–2.52Authors' conclusion
SHR was a significant predictor for adverse CV outcomes in CTVD patients with or without diabetes, which suggested that it could aid in the risk stratification in this particular population regardless of glucose metabolism status.
Study context
- Population
- Patients with coronary three-vessel disease (CTVD) undergoing percutaneous coronary intervention (PCI)
- Participants
- 10,532 patients
- Exposure
- High vs low stress hyperglycemia ratio
- Outcome
- CV events: cardiac death and non-fatal myocardial infarction (MI)
- Follow-up
- Median 3 years
Methodological detailsconsecutively enrolled, multivariable Cox regression
- Consecutively enrolled
- Multivariable Cox regression
Main finding
CV events
Hazard ratio
1.99
95% CI 1.58–2.52
P < 0.001
SHR Highvs SHR Low
HR 1.99 (95% CI 1.58–2.52); P < 0.001
As reported in the abstract
- Total cardiovascular (CV) events
- 279 (2.6%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CV events, patients with diabetes | 1.50 (1.08–2.10) | P = 0.016 | |
| CV events, patients without diabetes | 1.97 (1.42–2.72) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Discrimination and reclassification
- Adding stress hyperglycemia ratio (SHR) to base model of traditional risk factors significantly improved C-index, net reclassification and integrated discrimination
Original publication
High stress hyperglycemia ratio predicts adverse clinical outcome in patients with coronary three-vessel disease: a large-scale cohort study. Cardiovasc Diabetol. Published 1 June 2024. doi:10.
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