High Prevalence of Hypercalcitoninemia in a Large Cohort of Adult and Pediatric Patients With Parathyroid Hormone (PTH) Resistance Syndromes
Authors' conclusion
This study underscores the common occurrence of hypercalcitoninemia in both pediatric and adult patients with PHP/iPPSD, in particular with subtypes iPPSD2 and iPPSD3. Furthermore, these patients show hyperresponsiveness to calcium stimulation tests falling between healthy subjects and patients with MTC. These findings contribute to the understanding of CT dynamics in the context of PHP/iPPSD.
Study context
- Population
- Pediatric and adult patients with pseudohypoparathyroidism (PHP)/inactivating PTH/PTHrP disorders (iPPSD)
- Participants
- 88 vs 43
- Exposure
- Pediatric vs Adult
- Pediatricn = 88
- Adultn = 43
- Outcome
- Characteristics of hypercalcitoninemia
Methodological details2 European endocrinology tertiary centers, Other etiologies of hypercalcitoninemia excluded; adults underwent regular thyroid US to screen for medullary thyroid cancer (MTC)
- 2 European endocrinology tertiary centers
- Other etiologies of hypercalcitoninemia excluded; adults underwent regular thyroid US to screen for MTC
Main finding
As reported in the abstract
Hypercalcitoninemia
| Group | Value | Median calcitonin (CT) | Mean CT |
|---|---|---|---|
| Pediatric | 65.9% | 15 ng/L | |
| Adult | 53.5% | 21.6 ng/L |
Value
Pediatric65.9%
Adult53.5%
Median calcitonin (CT)
Pediatric15 ng/L
Adult— not stated in the abstract
Mean CT
Pediatric— not stated in the abstract
Adult21.6 ng/L
Observational data: associations, not effects.
Further findings
CT levels over follow-up in adults · median follow-up 134.5 months
- Stable CT levels in adults
Correlation between CT and PTH
- No correlations detected between CT and PTH levels
Calcium stimulation tests in adults
- Calcium stimulation tests performed
- 20
- Significant difference in basal and peak CT vs healthy subjects and subjects with MTC; no difference vs patients with C-cell hyperplasia
Original publication
High Prevalence of Hypercalcitoninemia in a Large Cohort of Adult and Pediatric Patients With PTH Resistance Syndromes. J Clin Endocrinol Metab. Published 28 June 2024. doi:10.
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