High Incidence of Diabetes Mellitus After Distal Pancreatectomy and Its Predictors: A Long-term Follow-up Study
Authors' conclusion
Impaired glucose tolerance and reduced early-phase insulin response to glucose are involved in the development of new-onset diabetes after DP; the latter is an additional factor in the development of diabetes and becomes apparent when pancreatic beta cell mass is reduced after DP.
Study context
- Population
- Patients without diabetes before surgery who underwent distal pancreatectomy (DP)
- Participants
- 56 patients
- Outcome
- Cumulative incidence of DM after DP
- Follow-up
- Up to 36 months
Methodological detailslong-term follow-up
- Long-term follow-up
Main finding
As reported in the abstract
Incidence of DM after DP
Developed DM
33 of 56
Cumulative incidence of DM at 36 months
74.1%
Observational data: associations, not effects.
Further findings
Insulin secretion and blood glucose after DP
- Insulin secretion decreased and blood glucose levels worsened after DP
Residual pancreatic volume
- Significantly associated with reserve capacity of insulin secretion but not with blood glucose levels or development of DM
Risk factors for DM after DP (multivariate Cox regression)
- Preoperative impaired glucose tolerance, and decreased insulinogenic index and impaired glucose tolerance at 1 month postoperatively, were risk factors
Original publication
High Incidence of Diabetes Mellitus After Distal Pancreatectomy and Its Predictors: A Long-term Follow-up Study. J Clin Endocrinol Metab. Published 27 October 2023. doi:10.
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