Gestational diabetes & diabetes in pregnancy
High Incidence of Gestational Diabetes Mellitus in Females With Cystic Fibrosis Persists in the Triple Cystic Fibrosis Transmembrane Conductance Regulator Modulator Era: Implications for Screening
Authors' conclusion
Despite improved CF health status, elevated GDM risk persists in FwCF relative to the general population. Recognition of value and indication for 2 oral glucose tolerance tests for GDM screening is evident as almost 50% cases were detected early.
Study context
- Population
- Females with cystic fibrosis (FwCF) who completed pregnancies between September 2020 and November 2025, cystic fibrosis (CF) Reproductive and Maternal Health Service; CF-related diabetes or prepregnancy dysglycemia excludedpregnancies in 45 FwCF
- Participants
- 57 females
- Exposure
- FwCF developing gestational diabetes mellitus (GDM) vs no GDM
- GDMn = 27
- Outcome
- Incidence and timing of GDM diagnosis
Methodological detailsquality improvement evaluation, single service, 19/77 (25%) with CF-related diabetes (CFRD) excluded; 1 removed due to insufficient data
- Quality improvement evaluation
- Single service
- 19/77 (25%) with CFRD excluded; 1 removed due to insufficient data
Main finding
As reported in the abstract
Pregnancies complicated by GDM
GDM
47%
27
- GDM diagnoses made at an early OGTT
- ≈48%
Observational data: associations, not effects.
Further findings
BMI · preconception
P < 0.05
Age, spirometry and preconception A1C
- No significant differences in age, spirometry, or preconception A1C between GDM and no GDM
Pancreatic exocrine insufficiency
- FwCF with pancreatic exocrine insufficiency were significantly more likely to develop GDM
Original publication
High Incidence of Gestational Diabetes Mellitus in Females With Cystic Fibrosis Persists in the Triple Cystic Fibrosis Transmembrane Conductance Regulator Modulator Era: Implications for Screening. Endocr Pract. Published 23 March 2026. doi:10.
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