High glutamic acid decarboxylase antibody titers may be associated with a decline in β-cell function over time and future insulin deficiency in latent autoimmune diabetes in adults
Authors' conclusion
GADA-ELISA titer of ≥180 U/mL, especially with HLA-DRB1*04:05, might reflect higher disease activity and may be associated with decline in β-cell function over time and future insulin dependency in LADA.
Study context
- Population
- Participants with latent autoimmune diabetes in adults (LADA)
- Participants
- 63 participants
- Exposure
- GADA by enzyme-linked immunosorbent assay (GADA-ELISA) titer ≥180 U/mL vs <180 U/mL
- Outcome
- Association between disease duration and C-peptide index (β-cell function) by GADA-ELISA titer
Main finding
As reported in the abstract
Significant inverse correlation in ≥180 U/mL, Spearman's rs
−0.516
p < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Positivity rate of insulin peptide-specific inflammatory immunoreactivitySignificantly higher with ≥180 U/mL | P < 0.05 |
Correlation between disease duration and C-peptide index, HLA-DRB1*04:05 subgroup
- Significant inverse correlation in ≥180 U/mL with HLA-DRB1*04:05, rs
- −0.751, p < 0.01
Original publication
High glutamic acid decarboxylase antibody titers may be associated with a decline in β-cell function over time and future insulin deficiency in latent autoimmune diabetes in adults. Diabetes Res Clin Pract. Published 30 July 2024. doi:10.
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