High-density Lipoprotein Over Midlife and Future Cognition in Women: The SWAN High-density Lipoproteins (HDL) Ancillary Study
Authors' conclusion
Enhancing specific serum HDL metrics during midlife could be promising in cognitive restoration, particularly memory, the initial and predominant symptom of Alzheimer's disease.
Study context
- Population
- Midlife women from the Study of Women's Health Across the Nation HDL ancillary study; age at baseline 50.2 ± 2.9 years1,234 observations
- Participants
- 503 women
- Exposure
- Serum HDL metrics at midlife and their changes over midlife vs subsequent cognitive performance
- Outcome
- Cognitive performance: working memory (Digit Span Backward Test), processing speed (Symbol Digit Modalities Test), episodic memory immediate and delayed recall (East Boston Memory Test), assessed repeatedly (maximum 5 times)
- Follow-up
- 7.72 ± 4.10 years
Methodological detailsSWAN HDL ancillary study, joint models
- SWAN HDL ancillary study
- Joint models
Main finding
As reported in the abstract
Associations of HDL metrics with subsequent cognitive performance
- Higher total HDL particle (HDL-P) and smaller HDL size at midlife were associated with better subsequent immediate recall, delayed recall and/or processing speed
- Greater increase in HDL-PL, apoA-1, medium HDL-P and total HDL-P and less increase in HDL size over midlife were associated with better subsequent immediate and/or delayed recall
Observational data: associations, not effects.
Original publication
High-density Lipoprotein Over Midlife and Future Cognition in Women: The SWAN HDL Ancillary Study. J Clin Endocrinol Metab. Published 5 October 2024. doi:10.
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