Serum 25-Hydroxyvitamin D, Genetic Susceptibility, and Abdominal Aortic Aneurysm Risk
Main finding · Incident AAA (2042 cases)Result — go to the resultHazard ratio 0.92 95% CI 0.88–0.96Authors' conclusion
There was a significant inverse association between serum 25(OH)D and AAA incidence, particularly among individuals with higher genetic risk for AAA, older age, and without diabetics.
Study context
- Population
- UK Biobank participants without prevalent aortic aneurysm or aortic dissection at baseline
- Participants
- 447,529 participants
- Exposure
- Serum 25D concentration and genetic variants vs incident abdominal aortic aneurysm (AAA)
- Outcome
- Incident abdominal aortic aneurysm (AAA)
- Follow-up
- Median 12.5 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
Incident AAA (2042 cases)
Hazard ratio
0.92
95% CI 0.88–0.96
Per SD increment in serum 25(OH)D
HR 0.92 (95% CI 0.88–0.96)
Per SD increment in serum 25, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| ApaI SNP and incident AAA (371 621 with genetics assessment)ApaI AA allelesvs ApaI CC alleles | 1.16 (1.02–1.32) | |
| 0.512Hazard ratio (log scale) |
Effect modification of 25(OH)D–AAA association by age and diabetes
- Inverse association more pronounced in older individuals and those without diabetes
- both P for interaction < .05
Effect modification by genetic risk for AAA
- Inverse association stronger with intermediate or high genetic risk for AAA
- P for interaction = 0.048
Original publication
Serum 25-Hydroxyvitamin D, Genetic Susceptibility, and Abdominal Aortic Aneurysm Risk. J Clin Endocrinol Metab. Published 4 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →