Overexpression of NR1D1 Portends Disease Recurrence in Thyroid Cancer
Authors' conclusion
NR1D1 is overexpressed in malignant thyroid tumors and has prognostic significance. Our findings suggest therapeutic potential in targeting NR1D1 for thyroid cancer.
Study context
- Population
- Thyroid follicular epithelial-derived cancers, with normal thyroid tissue and benign nodular goiter
- Comparison
- High vs low NR1D1 expression in thyroid cancer
- Outcome
- NR1D1 expression and its correlates
Methodological detailsimmunohistochemical analysis, in vitro and in vivo experiments
- Immunohistochemical analysis
- In vitro and in vivo experiments
Main finding
As reported in the abstract
- Nuclear NR1D1 expression present in thyroid follicular epithelial-derived cancers; none detectable in normal thyroid tissue or benign nodular goiter
- High NR1D1 had more advanced disease stages, extrathyroidal extension, lymphovascular invasion and shorter recurrence-free survival vs low NR1D1
- NR1D1 modulation affected organoid growth, anoikis resistance, and invasive and migratory capacity of thyroid cancer cells
- Invasion-promoting effect of NR1D1 regulated by the β-catenin/ZEB1 axis
- NR1D1 overexpression accelerated xenograft growth and lung metastasis in vivo
Original publication
Overexpression of NR1D1 Portends Disease Recurrence in Thyroid Cancer. J Clin Endocrinol Metab. Published 3 October 2024. doi:10.
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