Hepatic insulin resistance and muscle insulin resistance are characterized by distinct postprandial plasma metabolite profiles: a cross-sectional study
Authors' conclusion
People with muscle IR or liver IR have distinct postprandial plasma metabolite profiles, with more unfavorable postprandial metabolite responses in those with liver IR compared to muscle IR.
Study context
- Population
- Women and men with BMI 25–40 kg/m², aged 40–75 years, with predominant muscle insulin resistance (IR) or liver IR
- Participants
- 214 women
- Exposure
- Predominant liver IR vs predominant muscle IR
- Outcome
- Postprandial plasma metabolite iAUCs (247 NMR metabolite measures) after a high-fat mixed meal
- Follow-up
- T = 0, 30, 60, 120, 240 min
Main finding
As reported in the abstract
Postprandial plasma metabolite iAUCs, liver IR vs muscle IR
- Postprandial metabolite iAUCs significantly different between liver and muscle IR
- 68
Observational data: associations, not effects.
Original publication
Hepatic insulin resistance and muscle insulin resistance are characterized by distinct postprandial plasma metabolite profiles: a cross-sectional study. Cardiovasc Diabetol. Published 16 March 2024. doi:10.
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