Interaction between breastfeeding duration and an obesity genetic risk score to predict body fat composition in European adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study
Authors' conclusion
Breastfeeding modulates the association between the obesity GRS and body composition in adolescents.
Study context
- Population
- European adolescents, HELENA study
- Participants
- 751 adolescents
- Exposure
- Breastfeeding duration (1-3 months, ≥4 months) vs never breastfed, and interaction with obesity genetic risk score (GRS)
- Outcome
- Effect of breastfeeding duration and its interaction with an obesity GRS on adiposity measures
Methodological detailsmultiple linear regression adjusted for socioeconomic status and lifestyle factors
- Multiple linear regression adjusted for socioeconomic status and lifestyle factors
Main finding
As reported in the abstract
Adiposity measures (WC, BMI and FMI z-scores)
- ≥4 months · main effect
- β, waist circumference (WC) z-score −0.189 (95% CI −0.37 to −0.00); P = 0.044
- 1-3 months
- β, interaction with obesity GRS, body mass index (BMI) z-score 0.155 (95% CI 0.06–0.24); P = 0.001
- ≥4 months
- β, interaction with obesity GRS, BMI z-score 0.108 (95% CI 0.01–0.18); P = 0.020
- 1-3 months
- β, interaction with obesity GRS, fat mass index (FMI) z-score 0.134 (95% CI 0.04–0.22); P = 0.003
- ≥4 months
- β, interaction with obesity GRS, FMI z-score 0.100 (95% CI 0.01–0.18); P = 0.026
Observational data: associations, not effects.
Original publication
Interaction between breastfeeding duration and an obesity genetic risk score to predict body fat composition in European adolescents: The HELENA study. Pediatr Obes. Published 21 January 2025. doi:10.
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