Heavy Metals and Trajectories of Anti-Müllerian Hormone During the Menopausal Transition
Authors' conclusion
Heavy metals including arsenic, cadmium, and mercury may act as ovarian toxicants by diminishing ovarian reserve in women approaching the FMP.
Study context
- Population
- Women in the Study of Women's Health Across the Nation with repeated anti-Müllerian hormone (AMH) measurements from 10 to 0 years before the final menstrual period (FMP)2,252 AMH measurements
- Participants
- 549 women
- Exposure
- Highest vs lowest tertile of urinary heavy metals
- Outcome
- Serum AMH concentration (picoAMH ELISA)
- Follow-up
- At the FMP
Methodological detailslongitudinal, repeated AMH measurements, multivariable linear mixed regression
- Longitudinal
- Repeated AMH measurements
- Multivariable linear mixed regression
Main finding
As reported in the abstract
AMH at the FMP, highest vs lowest tertile (adjusted)
Highest tertile vs Lowest tertilePercent change, % (95% CI)P value
Arsenic
−32.1(−52.9 to −2.2)
P = 0.03for trendMercury
−40.7(−58.9 to −14.5)
P = 0.005for trendObservational data: associations, not effects.
Further findings
| Outcome | Percent change per year (%) (95% CI) | P value | |
|---|---|---|---|
| Rate of decline in AMH over time with higher metal concentrationBetween Highest tertile and Lowest tertile · cadmium | −9.0 (−15.5 to −1.9) | P for trend = 0.01 | |
| Rate of decline in AMH over time with higher metal concentrationBetween Highest tertile and Lowest tertile · mercury | −7.3 (−14.0 to −0.1) | P for trend = 0.04 | |
| −20−10010Difference, % (linear scale) |
Original publication
Heavy Metals and Trajectories of Anti-Müllerian Hormone During the Menopausal Transition. J Clin Endocrinol Metab. Published 25 January 2024. doi:10.
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