Heart Rate Variability and Incident Type 2 Diabetes in General Population
Authors' conclusion
Autonomic dysfunction precedes development of T2D, especially among younger individuals, while MR analysis suggests no causal relationship. More studies are needed to further validate our findings.
Study context
- Population
- Participants of the population-based Rotterdam Study without history of T2D and AF at baseline, with repeated heart rate variability (HRV) assessments; mean age 63.7 years, 58% women
- Participants
- 7,630 participants
- Exposure
- Longitudinal evolution of heart rate and HRV metrics vs incident T2D
- Outcome
- Incident T2D
- Follow-up
- Median 8.6 years
Methodological detailsjoint models, adjusted for cardiovascular risk factors, bidirectional Mendelian randomization
- Joint models
- Adjusted for cardiovascular risk factors
- Bidirectional Mendelian randomization
Main finding
As reported in the abstract
Developed incident T2D
871 individuals
HR per 1 SD increase in heart rate
1.20
95% CI 1.09–1.33
HR per 1 SD increase in log(RMSSDc)
1.16
95% CI 1.01–1.33
Observational data: associations, not effects.
Further findings
Heart rate and incident T2D by age subgroup
- HR, age <62 years
- 1.54 (95% CI, 1.08-2.06)
- HR, age >62 years
- 1.15 (95% CI, 1.01-1.31)
- P for interaction
- <.001
Bidirectional Mendelian randomization (MR)
- HRV and T2D were not significantly related to each other
Original publication
Heart Rate Variability and Incident Type 2 Diabetes in General Population. J Clin Endocrinol Metab. Published 6 April 2023. doi:10.
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