Healthy lifestyle and all‐cause and cause‐specific dementia in individuals with type 2 diabetes and the roles of diabetes duration and insulin use in UK Biobank cohort
Main finding · All-cause dementiaResult — go to the resultHazard ratio 3.14 95% CI 2.34–4.21Authors' conclusion
In people with T2DM, higher healthy lifestyle score was associated with lower risk of all-cause dementia. Diabetes duration and insulin use moderated the association between healthy lifestyle score and risk of dementia.
Study context
- Population
- UK Biobank participants; healthy lifestyle score from seven lifestyle factors recommended by diabetes management guidelines
- Participants
- 459,840 participants
- Exposure
- Healthy lifestyle score categories (0-1, 2-3, 4, 5-7) in people with T2D vs diabetes-free participants scoring 5-7
- Outcome
- All-cause dementia
Methodological detailsUK Biobank, Cox proportional hazards models
- UK Biobank
- Cox proportional hazards models
Main finding
As reported in the abstract
Hazard ratio
3.14
95% CI 2.34–4.21
T2D, score 0-1vs Diabetes-free, score 5-7
HR 3.14 (95% CI 2.34–4.21)
- T2D scored 2-3, 4 and 5-7 vs reference: around two-time risk (HR range)
- 2.20-2.36
Observational data: associations, not effects.
Further findings
Vascular dementia in T2D, per 2-point increase in score
- HR per 2-point increase (dose-response trend)
- 0.75 (0.61-0.93)
Alzheimer's disease in T2D, per 2-point increase in score
- HR per 2-point increase; no significant association
- 0.95 (0.77-1.16)
Effect modification by diabetes duration and insulin use
- Reduced risk of all-cause and cause-specific dementia with higher score observed with diabetes duration <10 years, or with no insulin use
Original publication
Healthy lifestyle and all‐cause and cause‐specific dementia in individuals with type 2 diabetes and the roles of diabetes duration and insulin use in UK Biobank cohort. Diabetes Obes Metab. Published 12 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →