The effects of long-term cumulative HbA1c exposure on the development and onset time of dementia in the patients with type 2 diabetes mellitus: Hospital based retrospective study (2005–2021)
Authors' conclusion
Our results indicate poorly controlled T2DM was associated with an increased risk of developing dementia, as measured by AUCHbA1c and HbA1cavg. Higher cumulative glycemic exposure may lead to developing dementia in a shorter time.
Study context
- Population
- Patients with T2DM identified in the electronic medical record at Severance Hospital, Korea
- Participants
- 20,487 records
- Exposure
- Patients who developed dementia vs those who did not
- Outcome
- Development of dementia and time to dementia by cumulative HbA1c (AUCHbA1c) and mean HbA1c over time (HbA1cavg)
Methodological detailshospital-based, single-centre
- Hospital-based
- Single-centre
Main finding
As reported in the abstract
Cumulative HbA1c (AUCHbA1c)
Observational data: associations, not effects.
Further findings
Mean HbA1c over time (HbA1cavg)
| Outcome | β (days) (95% CI) |
|---|---|
| Time to dementia onset per increase in HbA1cavg, among those who developed dementiaTime to onset decreased as HbA1cavg increased | −380.6 (−416.2 to −345.0) |
Mean HbA1c over time (HbA1cavg)
- HbA1cavg significantly higher in those who later developed dementia
- OR of dementia increased when HbA1cavg was 7.2% (55 mmol/mol) or above
Original publication
The effects of long-term cumulative HbA1c exposure on the development and onset time of dementia in the patients with type 2 diabetes mellitus: Hospital based retrospective study (2005–2021). Diabetes Res Clin Pract. Published 16 May 2023. doi:10.
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