Health-related quality of life and management routine in painful and painless diabetic polyneuropathy (PREDIP study)
Authors' conclusion
Although not only severe/moderate but also mild neuropathic pain are powerful risk factors of reduced health-related quality of life, painful DSPN still remains undertreated, whilst screening tools are underutilized in real-world practice.
Study context
- Population
- People with possible/probable diabetic sensorimotor polyneuropathy (DSPN) from practices or clinics, classified by the numerical pain rating scale
- Participants
- 617 people
- Exposure
- Severe/moderate painful DSPN vs mild painful DSPN vs painless DSPN
- Group 1n = 262
- Group 2n = 210
- Group 3n = 145reference
- Outcome
- Real-world management routine and impact of neuropathic pain severity on health-related quality of life (SF-12)
Methodological detailsnon-interventional, multicentre
- Non-interventional
- Multicentre
Main finding
As reported in the abstract
Group 1: received any pharmacotherapy for DSPN
42%
Group 1: received analgesic pharmacotherapy for DSPN
28%
Use of three different DSPN screening tools
77%, 54%, and 28%
Observational data: associations, not effects.
Further findings
Factors associated with severe/moderate painful DSPN
- Severe/moderate painful DSPN associated with female sex, higher BMI and longer diabetes duration
- P < 0.05
Original publication
Health-related quality of life and management routine in painful and painless diabetic polyneuropathy (PREDIP study). Diabetes Res Clin Pract. Published 1 July 2026. doi:10.
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