Health-related quality of life analyses in nonfunctioning pituitary macroadenoma patients identifies at-risk populations
Authors' conclusion
Hypopituitarism, radiation therapy after TSS, and financial stressors are associated with more impaired QoL in patients with NFPMA. Awareness of these factors can better guide use and timing of radiation therapy in addition to identifying patients who can benefit from multidisciplinary surveillance.
Study context
- Population
- Patients with treated nonfunctioning pituitary macroadenoma (nonfunctioning pituitary macroadenomas (NFPMA)), >1 year follow-up after transsphenoidal surgery (TSS), no evidence of progressive disease25% received radiation therapy (RT)
- Participants
- 229 patients
- Exposure
- RT vs no RT after TSS; hypopituitarism vs none; financial stressor vs none
- Outcome
- Patient-reported QoL (RAND-36, Multidimensional Fatigue Inventory, Cognitive Failures Questionnaire)
- Follow-up
- Median 7.7 years after initial TSS
Main finding
As reported in the abstract
Patient-reported QoL · median 7.7 years after TSS
- Hypopituitarism: worse energy and fatigue and cognitive function
- p < 0.03
Observational data: associations, not effects.
Further findings
Baseline characteristics, RT vs no RT
- RT patients younger (median age 46 v 58)
- P < 0.0001
- RT patients had larger tumors (28 mm v 22 mm)
- P < 0.0001
- RT patients more likely to have visual symptoms (65% v 34%)
- P = 0.0002
- RT patients more likely to have hypopituitarism (93% v 62%)
- P < 0.0001
- Time from initial TSS to RT, median (range)
- 2.0 years (0.1-22.5)
Original publication
Health-related quality of life analyses in nonfunctioning pituitary macroadenoma patients identifies at-risk populations. Pituitary. Published 21 July 2023. doi:10.
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