Gut Microbial Changes Associated With Obesity in Youth With Type 1 Diabetes
Authors' conclusion
Our findings identify a gut microbiome and microbial metabolite signature associated with obesity in T1D. These findings could help identify gut microbiome-targeted therapies to manage obesity in T1D.
Study context
- Population
- Youth with T1D; mean age 15.3 ± 2.2 years, HbA1c 7.8 ± 1.3%, diabetes duration 5.1 ± 4.4 years, 42.0% female, 94.0% White
- Participants
- 21 vs 27
- Exposure
- Obese vs lean T1D youth
- Obesen = 21
- Leann = 27reference
- Outcome
- Gut microbial (metagenomic shotgun sequencing) and stool short-chain fatty acid (SCFA) differences
Methodological detailspilot study
- Pilot study
Main finding
As reported in the abstract
Gut microbiome
- Increased relative abundance of Prevotella copri, among other taxa, in obese
- Upregulated branched-chain amino acid (BCAA) biosynthesis in obese; upregulated BCAA degradation, tyrosine metabolism and secondary bile acid biosynthesis in lean
- Obese vs Lean: P = 0.013
- Obese vs Lean: P = 0.0058
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Stool SCFAsHigher in obese | P < 0.05 for all |
Original publication
Gut Microbial Changes Associated With Obesity in Youth With Type 1 Diabetes. J Clin Endocrinol Metab. Published 31 July 2024. doi:10.
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