Cluster analysis of adult individuals with type 1 diabetes: Treatment pathways and complications over a five-year follow-up period
Authors' conclusion
Clinical characteristics can identify subgroups of patients with T1DM showing differences in treatment and complications during follow-up.
Study context
- Population
- Adults with T1D, T1DExchange Registry
- Participants
- 6,302 adults
- Exposure
- Five data-driven clusters of adults with T1D
- Outcome
- Subgroups of adults with T1D, their treatment pathways and risk of diabetes-related complications
- Follow-up
- 5-year follow-up
Methodological detailsk-means cluster analysis, Cox regression, 5-year follow-up
- K-means cluster analysis
- Cox regression
- 5-year follow-up
Main finding
As reported in the abstract
Cluster distribution
Observational data: associations, not effects.
Further findings
Treatment pathways
- Technology adoption showed improved glycaemic control over time
Complication risk (Cox proportional hazards)
- Cluster 1: low complication risk
- Cluster 2: highest risk for retinopathy, coronary artery disease and autonomic neuropathy
- Cluster 3: highest risk for albuminuria, depression and DKA
- Cluster 4: increased risk for multiple complications
- Cluster 5: highest risk for hypertension and severe hypoglycaemia, elevated coronary artery disease risk
Original publication
Cluster analysis of adult individuals with type 1 diabetes: Treatment pathways and complications over a five-year follow-up period. Diabetes Res Clin Pract. Published 30 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →