Growth hormone therapy is associated with improved uterine dimensions in girls with Turner syndrome prior to oestrogen replacement
Authors' conclusion
GH therapy has a stimulatory effect on uterine dimensions in pre-and peripubertal girls with TS. Earlier initiation and longer duration of GH is important in TS girls before ERT.
Study context
- Population
- Premenarchal girls with Turner syndrome (TS), aged 5–15 years, pubertal stage B1-B3, not having received ERT
- Exposure
- Growth hormone (GH) recipients vs nonrecipients among girls with TS; TS vs age-matched controls
- Outcome
- UtVol-SDS in girls with TS
Methodological detailsage-matched healthy controls
- Age-matched healthy controls
Main finding
As reported in the abstract
GH recipients
−0.63
Nonrecipients
−1.39
P = 0.0001
- UtL-SDS higher in GH recipients vs nonrecipients (−1.73 vs. −6.49)
- P < 0.0001
- GH use independently predicted normal uterine volume for age (NUVA) (adjusted for pubertal status, karyotype and height-SDS), OR
- 5.09 (CI 1.63-15.94; p = .005)
Observational data: associations, not effects.
Further findings
Median UtVol-SDS, UtL-SDS and MOV-SDS, TS vs age-matched controls
- UtVol-SDS, TS vs controls (p < .001)
- −1.07 vs. 0.86
- UtL-SDS, TS vs controls (p < .001)
- −3.72 vs. −0.41
- MOV-SDS, TS vs controls (p < .001)
- −5.53 vs. 1.96
GH initiation and duration, NUVA (n = 29) vs low uterine volume (UtVol) for age (n = 44)
- Age at GH initiation, NUVA vs low UtVol (earlier with NUVA; p = .03)
- 7.8 vs. 9.3 years
- Duration of GH, NUVA vs low UtVol (longer with NUVA; p = .002)
- 3.71 vs. 2.14 years
Correlations of UtVol-SDS with GH
- With duration of GH (p = .01)
- ρ = 0.411
- With age at GH initiation (p = .003)
- ρ = −0.479
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Growth hormone therapy is associated with improved uterine dimensions in girls with Turner syndrome prior to oestrogen replacement. Clin Endocrinol (Oxf). Published 9 August 2023. doi:10.
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