Clinical Phenotype of Graves Disease in Autoimmune Polyglandular Syndrome or as Isolated Disease: The GRAPHE Study
Authors' conclusion
The results of the present study show that, despite similar clinical and biochemical phenotype at presentation, a more severe clinical course characterizes isolated GD patients compared to those whose disease is a feature of autoimmune polyglandular syndrome.
Study context
- Population
- Patients with graves disease (GD) diagnosed and regularly followed at outpatient clinics for Endocrinology, Nuclear Medicine and Clinical Surgery, January 1, 2010, to June 30, 2024; 77% women
- Participants
- 567 patients
- Exposure
- Isolated GD vs GD as part of autoimmune polyglandular syndrome
- Outcome
- Clinical course: Graves orbitopathy, definitive therapy, time from onset to definitive therapy
Main finding
As reported in the abstract
- Isolated GD vs GD1-APS and GD2-APS: P < 0.001
- Isolated GD vs GD1-APS and GD2-APS: P < 0.001
- Isolated GD vs GD1-APS and GD2-APS: P < 0.001
Observational data: associations, not effects.
Further findings
Characteristics at disease onset
- 3 groups superimposable for gender
- P = 0.086
- 3 groups superimposable for FT4
- P = 0.899
- 3 groups superimposable for FT3
- P = 0.434
- 3 groups superimposable for TRAb titers
- P = 0.882
- 3 groups superimposable for thyroid volume
- P = 0.840
Original publication
Clinical Phenotype of Graves Disease in Autoimmune Polyglandular Syndrome or as Isolated Disease: The GRAPHE Study. J Clin Endocrinol Metab. Published 1 March 2025. doi:10.
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