Glycemic variability and in-hospital death of critically ill patients and the role of ventricular arrhythmias
Authors' conclusion
High glycemic variability was an independent risk factor for in-hospital death in ICU patients, and the effect was caused in part by an increased risk of VA.
Study context
- Population
- Intensive care unit (ICU) patients in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database version 2.0; median age 64 years, 47.2% male, 64.0% white, 17.8% admitted to the cardiac ICU
- Participants
- 17,756 patients
- Exposure
- Glycemic variability and ventricular arrhythmias (VA) and in-hospital death
- Outcome
- Incidence of VA and in-hospital death
Methodological detailsMIMIC-IV database, KHB mediation analysis
- MIMIC-IV database
- KHB mediation analysis
Main finding
As reported in the abstract
VA, adjusted logistic model, OR per unit increase in log-transformed coefficient of variation (CV)
OR 1.21, 95% CI: 1.11-1.31
In-hospital death, adjusted logistic model, OR per unit increase in log-transformed CV
OR 1.30, 95% CI: 1.20-1.41
Share of effect of glycemic variability on in-hospital death related to increased risk of VA
3.85%
Observational data: associations, not effects.
Further findings
Total incidence
- VA
- 10.6%
- In-hospital death
- 12.8%
Original publication
Glycemic variability and in-hospital death of critically ill patients and the role of ventricular arrhythmias. Cardiovasc Diabetol. Published 12 June 2023. doi:10.
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