The impact of diabetes on the relationship of coronary artery disease and outcome: a study using multimodality imaging
Authors' conclusion
Coronary CTA followed by selective downstream use of PET myocardial perfusion imaging predicts long-term outcome similarly in non-diabetic and diabetic patients.
Study context
- Population
- Consecutive symptomatic patients undergoing coronary computed tomography angiography (CTA) for suspected coronary artery disease (CAD); Positron emission tomography (PET) myocardial perfusion imaging where obstructive CAD suspected on CTA
- Participants
- 1,743 patients
- Exposure
- No diabetes vs prediabetes vs T2D
- Non-diabeticn = 1,214reference
- Prediabeticn = 259
- Type 2 diabeticn = 270
- Outcome
- Composite of:
- All-cause mortality
- Myocardial infarction (MI)
- Unstable angina pectoris
- Follow-up
- Median 6.43 years
Methodological detailsconsecutive patients, multimodality imaging (coronary CTA with selective 15O-water PET myocardial perfusion imaging)
- Consecutive patients
- Multimodality imaging (coronary CTA with selective 15O-water PET myocardial perfusion imaging)
Main finding
As reported in the abstract
Composite adverse outcome:
- All-cause mortality
- MI
- Unstable angina pectoris (UAP)
Adverse events
164
106 deaths, 41 MIs, 17 UAPs
Annual event rate: normal coronary arteries vs concomitant T2D and hemodynamically significant CAD
0.2% vs. 4.7%
Observational data: associations, not effects.
Further findings
Hemodynamically significant CAD (abnormal perfusion)
| Outcome | Non-diabetic | Prediabetic | Type 2 diabetic |
|---|---|---|---|
| Normal coronary arteries on CTA | 39% | — not stated in the abstract | — not stated in the abstract |
— not stated in the abstract
Normal coronary arteries on CTA
- Prevalence highest in non-diabetic patients
Original publication
The impact of diabetes on the relationship of coronary artery disease and outcome: a study using multimodality imaging. Cardiovasc Diabetol. Published 31 May 2023. doi:10.
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