Glycemic Ratio Is a Superior Predictor of Mortality Compared With Stress Hyperglycemia Ratio in Critically Ill Patients

J Diabetes Sci TechnolPublished Retrospective cohort study

Authors' conclusion

Glycemic ratio was superior to SHR as a predictor of mortality. This study demonstrates that a mean ICU BG level representing 80% to 100% of the patient's EPBG was associated with the lowest mortality rate in a heterogeneous cohort of critically ill patients.

Study context

Population
Patients treated in a university-affiliated medical-surgical intensive care unit (ICU) from 2019 to 2023 with >4 ICU blood glucose (BG) measurements and HbA1c measured at admission
Participants
4,148 patients
Exposure
Glycemic ratio vs stress hyperglycemia ratio as predictors of mortality
Outcome
Mortality (prognostic ability of SHR and GR)
Methodological detailssingle-centre, university-affiliated medical-surgical ICU, prespecified glycemic ratio (GR) and stress hyperglycemia ratio (SHR) bands
  • Single-centre
  • University-affiliated medical-surgical ICU
  • Prespecified GR and SHR bands

Main finding

As reported in the abstract

Mortality in reference band 0.8 to <1.0

P = 0.0087

Observational data: associations, not effects.

Further findings

Mortality in stratum ≥1.4

P = 0.0376

Observed:expected mortality ratio (OEMR) vs reference band

GR <0.8 and GR >1.0 had higher OEMR vs reference band
P < 0.0001 for each
OEMR for SHR <0.8 and >1.0 vs reference band not significantly different

Original publication

Glycemic Ratio Is a Superior Predictor of Mortality Compared With Stress Hyperglycemia Ratio in Critically Ill Patients. J Diabetes Sci Technol. Published 24 July 2026. doi:10.1177/19322968261464561

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