Glycemic Outcomes During Outpatient Use of Automated Insulin Delivery Without Meal Announcement in Adults with Type 1 Diabetes: Results from the CLOSE IT Randomized Controlled Trial
Primary result · TIR 70-180 mg/dLResult — go to the resultAdjusted difference −2.2 percentage points 95% CI −6.2 to 1.7Authors' conclusion
In adults with type 1 diabetes, use of an open-source AID system without meal announcement demonstrated glycemic efficacy and achieved a similar time in the target glucose range to use of the same system as HCL.
Study context
- Population
- Adults with T1D aged 18–70 years established on an open-source automated insulin delivery (AID) system with meal announcement during a 12-week run-inrandomized 1:1
- Participants
- 73 adults
- Comparison
- AID without meal announcement vs HCL
- AID without meal announcementn = 36
- HCLn = 37reference
- Primary endpoint
- % time in target glucose range 70-180 mg/dL (3.9-10.0 mmol/L), adjusted for the same metric in the final 14 days of run-in
- Follow-up
- Final 14 days of the 12-week trial phase
Methodological detailsopen-label, parallel-arm, 12-week run-in phase
- Open-label
- Parallel-arm
- 12-week run-in phase
Primary result
TIR 70-180 mg/dL · end of trial phase
Adjusted difference
−2.2 percentage points
95% CI −6.2 to 1.7
By group
AID without meal announcementvs HCL
adjusted difference −2.2 percentage points (95% CI −6.2 to 1.7)
As reported in the abstract
Further findings
TIR 70-180 mg/dL at end of run-in · end of run-in phase
Original publication
Glycemic Outcomes During Outpatient Use of Automated Insulin Delivery Without Meal Announcement in Adults with Type 1 Diabetes: Results from the CLOSE IT Randomized Controlled Trial. Diabetes Technol Ther. Published 12 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →