Glycated Albumin Correlates With Time-in-Range Better Than Hemoglobin A1c (HbA1c) or Fructosamine
Authors' conclusion
GA is the most accurate predictor of TIR over 8 weeks compared with other glycemic indices, which may assist in clinical evaluation of changes in treatment where CGM is not possible and it is too early to use HbA1c
Study context
- Population
- Individuals with T1D and T2D using continuous glucose monitoring (CGM), 8 US clinicsIndividuals with T1D 18 · T2D 16
- Participants
- 34 individuals
- Comparison
- Glycated albumin (GA) vs HbA1c vs fructosamine correlation with CGM parameters
- Group 1n = 22
- Group 2n = 12
- Primary endpoint
- Pearson correlations between CGM and glycemic indices; ROC analysis of glycemic index values predictive of TIR >70%
- Follow-up
- 24 weeks
Methodological detailsexploratory comparative analyses, CGM subgroup, multicentre
- Exploratory comparative analyses
- CGM subgroup
- Multicentre
Primary result
As reported in the abstract
ROC: GA predicted time in range (TIR) >70% during weeks 2 to 24 (AUC)
>0.80
GA cutoff for TIR >70% (sensitivity and specificity 0.88)
17.5%
HbA1c cutoff for TIR >70% (sensitivity and specificity 0.86)
7.3%
Original publication
Glycated Albumin Correlates With Time-in-Range Better Than HbA1c or Fructosamine. J Clin Endocrinol Metab. Published 1 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →