Glucose and Psychosocial Outcomes 12 Months Following Transition from Multiple Daily Injections to Advanced Hybrid Closed Loop in Youth with Type 1 Diabetes and Suboptimal Glycemia
Authors' conclusion
After 12 months of AHCL usage, this study highlights the potential for substantial and sustained glycemic and psychosocial improvements among individuals experiencing considerable diabetes burden and suboptimal glycemia, following their switch from MDI to AHCL.
Study context
- Population
- Youth aged 13–25 years with T1D and suboptimal glycemia (HbA1c ≥8.5% [69 mmol/mol]) on multiple daily injections (MDI)19 continued advanced hybrid closed-loop (AHCL) at 12 months
- Participants
- 20 participants
- Exposure
- AHCL after transition from MDI vs baseline
- AHCLn = 20
- Outcome
- Time-in-range 70-180 mg/dL (3.9-10.0 mmol/L), baseline to 12 months
- Follow-up
- 12 months
Methodological details12-month extension phase, dual-center
- 12-month extension phase
- Dual-center
Main finding
As reported in the abstract
TIR at baseline (average ± SD)
27.6% ± 13.2%
TIR at 12 months (average ± SD)
62.5% ± 11.4%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Continued AHCL use · 12 months | AHCL 19 events |
- Continued AHCL use: 19 out of 20 participants
HbA1c, baseline to 12 months
- HbA1c at baseline
- 10.5% ± 2.1% (91.2 mmol/mol)
- HbA1c at 12 months
- 8.0% ± 0.9% (64.1 mmol/mol)
- Average improvement in HbA1c
- 2.5 percentage-point (27.1 mmol/mol)
Psychosocial outcomes · 12 months
- Improvements in general and diabetes-specific health-related quality of life and in diabetes treatment satisfaction
Safety
Per participant-year
- DKA rate after 12 months of AHCL
- 0.15
- DKA rate in the 12 months before the study
- 0.25
Original publication
Glucose and Psychosocial Outcomes 12 Months Following Transition from Multiple Daily Injections to Advanced Hybrid Closed Loop in Youth with Type 1 Diabetes and Suboptimal Glycemia. Diabetes Technol Ther. Published 7 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →