Diabetes technology

Glucose control during breakthrough SARS-CoV-2 infections in vaccinated patients with type 1 diabetes

Diabetes Res Clin PractPublished Retrospective study

Authors' conclusion

Breakthrough SARS-CoV-2 infection did not worsen glycemic control in vaccinated people with T1D.

Study context

Population
Continuous Glucose Monitoring (CGM) users with T1D vaccinated against COVID-19 who had a breakthrough SARS-CoV-2 infection between November 2021 and February 2022
Participants
106 users
Exposure
CGM metrics 14 days before vs during vs after breakthrough SARS-CoV-2 infection
Outcome
Trend of CGM-derived glycemic control metrics during SARS-CoV-2 infection

Main finding

As reported in the abstract

GMI · Time 3 vs Time 2

P = 0.006

Observational data: associations, not effects.

Further findings

OutcomeTime 2Time 3P value
TIR · Time 3 vs Time 2Significant increase at Time 352.1 ± 19.7 %54.6 ± 20.4 %P = 0.026
Glucose SD and CV · Time 3 and Time 2 vs Time 1 · significant reduction
P < 0.001
Glucose SD and CV · Time 3 and Time 2 vs Time 1 · significant reduction
P < 0.001

Glucose SD and CV · Time 3 and Time 2 vs Time 1

Associated with significant changes of mean glucose, TBR level 1 and total daily insulin doses

Original publication

Glucose control during breakthrough SARS-CoV-2 infections in vaccinated patients with type 1 diabetes. Diabetes Res Clin Pract. Published 9 December 2023. doi:10.1016/j.diabres.2023.111044

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