Type 2 & other diabetes

Global Diabetes Prevalence in COVID-19 Patients and Contribution to COVID-19– Related Severity and Mortality: A Systematic Review and Meta-analysis

Diabetes CarePublished Systematic review and meta-analysis

Authors' conclusion

The prevalence of diabetes increases with COVID-19 severity, and diabetes accounts for 9.5% of severe COVID-19 cases and 16.8% of deaths, with disparities according to country income, health care access and quality index, and diabetes disease burden.

Study context

Population
COVID-19 patients with known diagnosis and severity, with diabetes prevalence reported
Participants
29,874,938 patients729 studies
Comparison
Confirmed cases vs Nonhospitalized vs Hospitalized vs Nonsevere vs Severe vs Deceased
Outcome
Prevalence of diabetes in COVID-19 disease stages; PAF of diabetes to COVID-19-related severity and mortality
Methodological detailsmultivariate metaregression, modified comparative risk assessment model, subgroup analyses, Most studies had a high risk of bias
  • Multivariate metaregression
  • Modified comparative risk assessment model
  • Subgroup analyses
  • Most studies had a high risk of bias

Pooled result

As reported in the abstract

Pooled prevalence of diabetes
Overall population attributable fraction (PAF) of diabetes for severe COVID-19 disease
9.5% (7.3-11.7)
Overall PAF of diabetes for COVID-19-related deaths
16.8% (14.8-18.8)

Further pooled results

PAF by country subgroup

Countries with high income, high health care access and quality index, and low diabetes burden had lower PAF of diabetes to COVID-19 severity and death

Original publication

Global Diabetes Prevalence in COVID-19 Patients and Contribution to COVID-19– Related Severity and Mortality: A Systematic Review and Meta-analysis. Diabetes Care. Published 23 March 2023. doi:10.2337/dc22-1943

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