Global Diabetes Prevalence in COVID-19 Patients and Contribution to COVID-19– Related Severity and Mortality: A Systematic Review and Meta-analysis
Authors' conclusion
The prevalence of diabetes increases with COVID-19 severity, and diabetes accounts for 9.5% of severe COVID-19 cases and 16.8% of deaths, with disparities according to country income, health care access and quality index, and diabetes disease burden.
Study context
- Population
- COVID-19 patients with known diagnosis and severity, with diabetes prevalence reported
- Participants
- 29,874,938 patients729 studies
- Comparison
- Confirmed cases vs Nonhospitalized vs Hospitalized vs Nonsevere vs Severe vs Deceased
- Outcome
- Prevalence of diabetes in COVID-19 disease stages; PAF of diabetes to COVID-19-related severity and mortality
Methodological detailsmultivariate metaregression, modified comparative risk assessment model, subgroup analyses, Most studies had a high risk of bias
- Multivariate metaregression
- Modified comparative risk assessment model
- Subgroup analyses
- Most studies had a high risk of bias
Pooled result
As reported in the abstract
Pooled prevalence of diabetes
- Overall population attributable fraction (PAF) of diabetes for severe COVID-19 disease
- 9.5% (7.3-11.7)
- Overall PAF of diabetes for COVID-19-related deaths
- 16.8% (14.8-18.8)
Further pooled results
PAF by country subgroup
- Countries with high income, high health care access and quality index, and low diabetes burden had lower PAF of diabetes to COVID-19 severity and death
Original publication
Global Diabetes Prevalence in COVID-19 Patients and Contribution to COVID-19– Related Severity and Mortality: A Systematic Review and Meta-analysis. Diabetes Care. Published 23 March 2023. doi:10. 2337/ dc22-1943
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