Get ahead of the disease: Islet cell autoimmunity and preclinical phase of type 1 diabetes in general population of 1–9 year‐old children in the north‐eastern region of Poland —A summary of the first 18 months of the study
Authors' conclusion
Results confirm the importance of screening for IAbs in general paediatric population as a method of prediction of T1D development. The study also shows that patients with a single positive islet autoantibody may have already developed dysglycaemia and therefore need monitoring.
Study context
- Population
- Children aged 1–9 years from the general population of North-Eastern Poland
- Participants
- 3,575 children
- Outcome
- Islet autoimmunity and presymptomatic T1D
Methodological detailsgeneral population, stepwise autoantibody screening
- General population
- Stepwise autoantibody screening
Main finding
As reported in the abstract
Islet cell autoimmunity
Confirmed islet cell autoimmunity
7.78%
Multiple positive islet autoantibodies (IAbs) (of total)
1.17%
Observational data: associations, not effects.
Further findings
Individual autoantibodies
- IAAs most frequent
- 50.75%
- IA-2As least frequent
- 8.4%
- IAAs more frequent with T1D family history
- P = 0.04
- IAAs more frequent in children aged 1-3 years
- P = 0.02
- IA2-As frequency increased with age
- P = 0.035
- ZnT8As frequency increased with age
- P = 0.02
- ZnT8As more frequent in females
- P = 0.024
- Multiple positive IAbs almost 2.5-times higher with T1D family history than peers
Follow-up
- Children in follow-up
- 113
- Single autoantibody among those with dysglycaemia
- almost 67%
- Stage 3 diabetes, both diagnosed before DKA
- 2 (1.77%)
Original publication
Get ahead of the disease: Islet cell autoimmunity and preclinical phase of type 1 diabetes in general population of 1–9 year‐old children in the north‐eastern region of Poland —A summary of the first 18 months of the study. Diabetes Obes Metab. Published 24 June 2025. doi:10.
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