Gestational diabetes & diabetes in pregnancy
Gestational diabetes in South African women with HIV and HIV-seronegative women: results from the ORCHID cohort
Main finding · GDM prevalenceResult — go to the resultAdjusted odds ratio 0.57 95% CI 0.38–0.85Authors' conclusion
GDM prevalence in South Africa is similar to North America/Europe. Early GDM was diagnosed in a large majority of women who also exhibited features of poorer insulin sensitivity and beta cell function than those diagnosed late in pregnancy or without GDM. WWH had lower GDM risk than HIV-seronegative women.
Study context
- Population
- Pregnant women in South Africa enrolled at ≤18 weeks' gestation; median age 28 years, gestation 13 weeks
- Participants
- 1,573 women
- Exposure
- Women with HIV vs HIV-seronegative women
- Women with HIV (WWH)n = 668
- Outcome
- Prevalence of GDM (early and late) by 75 g OGTT using WHO criteria
- Follow-up
- Enrollment (early) and 32-36 weeks' gestation (late)
Main finding
GDM prevalence
Adjusted odds ratio
0.57
95% CI 0.38–0.85
By group
WWHvs HIV-seronegative
aOR 0.57 (95% CI 0.38–0.85)
As reported in the abstract
- Overall GDM prevalence
- 7.9%
- Early GDM among those with GDM
- 65%
Observational data: associations, not effects.
Further findings
Insulin sensitivity and beta cell function at enrollment by GDM timing
- Early GDM had the lowest Matsuda, Stumvoll, oral disposition index and glucose sensitivity vs late GDM and no GDM
Original publication
Gestational diabetes in South African women with HIV and HIV-seronegative women: results from the ORCHID cohort. J Clin Endocrinol Metab. Published 17 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →