Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study
Authors' conclusion
These findings reveal sex-specific associations between key LEAP2 gene variants and several obesity traits, while also indicating a strong independent association of LEAP2 variants with serum IGF-1 concentration.
Study context
- Population
- UK Biobank participants
- Outcome
- Associations of independent LEAP2 SNPs and GRSLEAP2 with obesity traits and serum IGF-1 concentration
Methodological detailsUK Biobank, linear and logistic regression, genetic risk score, sex-stratified analyses
- UK Biobank
- Linear and logistic regression
- Genetic risk score
- Sex-stratified analyses
Performance
As reported in the abstract
Single nucleotide polymorphisms (SNPs) positively associated with obesity-related traits
5
Independent SNPs positively associated with higher serum IGF-1 in both men and women
4
Original publication
Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin‐like growth factor‐1 concentration: A UK Biobank study. Diabetes Obes Metab. Published 18 June 2024. doi:10.
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