GLP1R haplotypes are associated with insulin secretion and sensitivity in children and adolescents with obesity
Authors' conclusion
GLP1R genetic variants, particularly rs6923761 and the A-C haplotype, are associated with distinct patterns of insulin secretion, insulin sensitivity, and circulating GLP-1 levels in children and adolescents with obesity.
Study context
- Population
- Italian children and adolescents with obesity26 in GLP-1 substudy
- Participants
- 1,025 children
- Exposure
- GLP1R SNPs and haplotypes vs metabolic traits and circulating GLP-1
- Outcome
- Associations of GLP1R variants with insulin secretion, sensitivity and circulating GLP-1
Methodological detailscohort, multivariable linear regression, mixed-effects models
- Cohort
- Multivariable linear regression
- Mixed-effects models
Main finding
As reported in the abstract
- rs6923761 variant associated with Matsuda index, IGI, AUCins and AUCins/AUCglu ratio
- p-all<0.031
- Haplotype A-C associated with lower FPI, HOMA-IR, IGI and AUCins
- p < 0.02
- Haplotype A-C associated with higher Matsuda index
- p = 0.009
- Haplotype A-C associated with lower GLP-1 concentrations
- p = 0.025
Observational data: associations, not effects.
Further findings
Circulating GLP-1 over time during OGTT · 120 min vs baseline
- Lower GLP-1 levels at 120 min vs baseline
- P < 0.001
Original publication
GLP1R haplotypes are associated with insulin secretion and sensitivity in children and adolescents with obesity. J Clin Endocrinol Metab. Published 17 July 2026. doi:10.
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