Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood
Authors' conclusion
Our results provide evidence of the protective effect of higher childhood BMI on insulin secretion and sensitivity, which are crucial intermediate diabetes traits. However, we stress that our results should not currently lead to any change in public health or clinical practice, given the uncertainty regarding the biological pathway of these effects and the limitations of this type of study.
Study context
- Population
- 441,761 individuals in the UK Biobank (childhood BMI estimated); external studies of T2D and oral and intravenous measures of insulin secretion and sensitivityUK Biobank
- Participants
- 441,761 participants
- Comparison
- Genetically predicted higher childhood BMI, independent of adulthood BMI
- Outcome
- Effect of childhood BMI 1 SD (1.97 kg/m²) higher, corrected for genetic liability to adulthood BMI
Methodological detailstwo-sample MR, multivariable (childhood BMI corrected for genetic liability to adulthood BMI)
- Two-sample MR
- Multivariable (childhood BMI corrected for genetic liability to adulthood BMI)
Main finding
As reported in the abstract
Insulin sensitivity index, β
0.15
95% CI 0.067, 0.225p=2.79×10-4
Fasting glucose, β
−0.053
95% CI −0.089, −0.017p=4.31×10-3
T2D, OR (95% CI 0.85, 1.04; p=0.228); little to no evidence of direct protective effect
0.94
Original publication
Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood. Diabetologia. Published 6 June 2023. doi:10.
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