Genetic Associations With C-peptide Levels Before Type 1 Diabetes Diagnosis in At-risk Relatives
Authors' conclusion
The type 2 diabetes-associated JAZF1 rs864745 T allele and higher T1D-GRS2 are associated with lower C-peptide AUC before diagnosis of type 1 diabetes, with implications for the design of prevention trials.
Study context
- Population
- Autoantibody-positive participants who developed T1D in the TrialNet Pathway to Prevention Study, with T1DExomeChip data
- Participants
- 713 participants
- Outcome
- AUC C-peptide levels during OGTTs, association with T1D-GRS2 and 16 known SNPs
- Follow-up
- 9 months before diagnosis
Methodological detailsretrospective analysis
- Retrospective analysis
Main finding
As reported in the abstract
C-peptide AUC in the 9 months before diagnosis
Higher T1D-GRS2 associated with lower C-peptide AUC, univariate β (P < .0001)
−.06
Higher T1D-GRS2 associated with lower C-peptide AUC, multivariate β (P = .005)
−.03
JAZF1 rs864745 T allele associated with lower C-peptide AUC, univariate β (P = .002)
−.11
JAZF1 rs864745 T allele associated with lower C-peptide AUC, multivariate β (P = .018)
−.06
Observational data: associations, not effects.
Original publication
Genetic Associations With C-peptide Levels Before Type 1 Diabetes Diagnosis in At-risk Relatives. J Clin Endocrinol Metab. Published 20 May 2024. doi:10.
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